Endocrine Abstracts

Neuropathy and ischemia play paramount roles in the pathogenesis of diabetic vascular complications. Reduced tissue blood flow in experimental diabetic complications can be corrected by several disease-modifying drugs. Actovegin (deproteinised hemoderivative product) is considered to be a potential agent to stimulate cellular energy metabolism and improve cell function. Testosterone vascular effects can be mediated via increasing cardiac and muscle activity and endothelium dep...

Background and Aim: One of the greatest problem in pregnancy, complicated by diabetes is screening and appropriate care for women, whose diabetes is manifested during pregnancy. The study is aimed at gathering epidemiological data on gestational diabetes mellitus (GDM) and evaluating the of appropriate therapy in this condition.Materials and Methods: Screening for GDM was carried out in – 692 pregnant women. GDM was observed in 3.3% (22 women) and i...

Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition with an autosomal dominant type of inheritance. It is evident that MEN2 is characterized by the presence of Medullary Thyroid Cancer (MTC) as a permanent symptom, the combination of which with pheochromocytoma and parathyroid syndrome is referred to as MEN-2A syndrome. The aim of our study was the creation of a database of patients with MTC and analysis of the data.Materials and methods...

The medical and social significance of the Multiple Endocrine Neoplasia type 2 (MEN2) is due to the severity of the manifestations of the disease components, namely the tumor process progression, a high risk of vascular accidents, pathological fractures of the femoral neck/spine, gastrointestinal bleeding, chronic renal failure. Late detection of pathology is associated with high mortality due to medullary thyroid cancer (MTC). Thus, the aim of the study was to establish the c...

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...

BackgroundMedullary thyroid cancer (MTC) is a calcitonin-producing C-cell tumor and accounts about 5% in the structure of thyroid malignancies. There are sporadic and hereditary variant of MTC, which is a mandatory component of endocrine neoplasia syndrome type 2. The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and demographic characteristics.Materials and methods<...

BackgroundThe management of patients with medullary thyroid cancer (MTC) has an important endocrinological aspect, because MTC can be a manifestation of multiple endocrine neoplasia syndrome (MEN), a genetically determined pathology with an autosomal dominant inheritance. MEN-2 syndrome is characterized by of MTC as a permanent feature, the combination with pheochromocytoma and/or adenoma of the parathyroid glands. The aim of the study was to determine t...